Metallacycle-mediated cross-coupling in natural product synthesis
نویسندگان
چکیده
منابع مشابه
“ Metathesis in Natural Product Synthesis ”
Institute of Organic Chemistry, Romanian Academy, 202B Spl. Independentei, PO Box 35-108, 060023 Bucharest, Romania; E-mail: *[email protected]; **[email protected] “Metathesis in Natural Product Synthesis” subtitled ‘Strategies, Substrates and Catalysts’ benefits from a foreword by Robert H. Grubbs, joint recipient of the 2005 Nobel Prize in Chemistry for his work on the development of the...
متن کاملNatural Product Synthesis
The Lycopodium alkaloids are a family of structurally complex natural products, which have provoked long-term interests in their total syntheses because of their unique and fascinating architectures and potential biological activities. In particular, fawcettimine-type Lycopodium alkaloids, such as fawcettimine (1) and fawcettidine (2) (Scheme 1), have attracted broad attention from the syntheti...
متن کاملCascade polycyclisations in natural product synthesis.
The efficient, stereocontrolled construction of polycyclic ring systems has long presented a formidable challenge to synthetic chemists. Cascade reactions offer a 'quick fix'--building multiple rings in a single step--and often dramatically shorten a synthetic route. In this Emerging Area article, a selection of the most recent and impressive examples of applications of this tactic to natural p...
متن کاملSynthesis of most polyene natural product motifs using just twelve building blocks and one coupling reaction
The inherent modularity of polypeptides, oligonucleotides and oligosaccharides has been harnessed to achieve generalized synthesis platforms. Importantly, like these other targets, most small-molecule natural products are biosynthesized via iterative coupling of bifunctional building blocks. This suggests that many small molecules also possess inherent modularity commensurate with systematic bu...
متن کاملComplex fragment coupling by crotylation: A powerful tool for polyketide natural product synthesis.
The first examples of the use of crotylation as a stereocontrolled complex fragment coupling strategy are described. Asymmetric aldehyde isoprenylation provides access to 2-substituted-1,3-butadienes that may be subjected to highly regio- and stereoselective 1,4 hydrosilylation with trichlorosilane. After complexation with a chiral diamine, the 2-sub-stituted-cis-crotylsilanes may be employed i...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Tetrahedron
سال: 2016
ISSN: 0040-4020
DOI: 10.1016/j.tet.2016.08.053